. 2022 Sep 20;11:e74777. doi: 10.7554/eLife.74777

Table 2. Association statistics for significant genome-wide loci.

Table 2—source data 1. Replication study.

The lead variants at the top four loci with p<5 × 10^–7 were genotyped in an independent European cohort of 395 posterior urethral valves (PUV) cases and 4151 controls. p-Values in the replication cohort were calculated using a one-sided Cochran Armitage Trend test. OR, odds ratio; CI, 95% confidence interval.

elife-74777-table2-data1.xlsx^{(10.5KB, xlsx)}

				P value		OR (95% CI)		Case EAF		Control EAF
Lead variant	CHR:POS	Effect Allele	Closest gene	Discovery	Replication	Discovery	Replication	Discovery	Replication	Discovery	Replication
rs10774740	chr12:114228397	T	TBX5	7.81x10^–12	5.17x10^–3	0.4	0.8	0.19	0.31	0.37	0.36
rs10774740	chr12:114228397	T	TBX5	7.81x10^–12	5.17x10^–3	(0.31–0.52)	(0.68–0.93)	0.19	0.31	0.37	0.36
rs144171242	chr6:43120356	G	PTK7	2.02x10^–8	7.21x10^–3	7.2	2.18	0.05	0.018	0.01	0.008
rs144171242	chr6:43120356	G	PTK7	2.02x10^–8	7.21x10^–3	(4.08–12.70)	(1.22–3.90)	0.05	0.018	0.01	0.008