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. 2022 Aug 9;6(10):2925–2936. doi: 10.1002/hep4.2045

TABLE 1.

Summary of studies and characteristics of patients included in the analysis.

Study Type of study Location Study period Total enrolled With cirrhosis With HCC Male % Mean age Surveillance modality
Atiq et al.[ 34 ] retrospective USA Jul 2010–Jul 2013 680 680 78 64.7 54.3 US & AFP
Caviglia et al.[ 12 ] retrospective Italy Nov 2012–Jan 2018 349 200 86 67 61 a AFP
Chalasani et al.[ 9 ] retrospective USA Jan 1994–Dec 1997 285 285 27 56 49 US & AFP
Chang et al.[ 13 ] retrospective Taiwan Jul 2002–Jul 2010 5664 1597 363 64.9 57 US, AFP, & US+AFP
Chun et al.[ 35 ] retrospective Korea Mar 2012–Aug 2013 49,381 48,122 24 91.4 60 AFP
Curley et al.[ 14 ] prospective USA Jan 1994–Dec 1997 416 140 36 58.8 54.8 US, AFP, & US+AFP
D'Onofrio et al.[ 36 ] retrospective Italy 2003–2006 128 128 57 62.5 46 US & AFP
Eltabbakh et al.[ 37 ] prospective Egypt Jun 2008–Jan 2011 1286 1286 102 35.4 51.5 US & US+AFP
Frey et al.[ 38 ] retrospective Switzerland 2011–2012 285 248 9 80 55 US
Gambarin‐Galwan et al.[ 10 ] retrospective USA 1 year (dates NA) 106 106 19 68.4 58.7 US, AFP, & US+AFP
Gopal et al.[ 15 ] retrospective USA Jan 2005–Jun 2012 1128 1128 452 78 55 AFP
Henrion[ 39 ] retrospective Belgium 1995 141 141 6 63.1 NA US, AFP, & US+AFP
Ishii et al.[ 40 ] prospective Japan Nov 1992–Mar 1994 918 299 29 78 66 AFP
Jasirwan et al.[ 16 ] retrospective Indonesia 2015–2017 330 66 132 71.2 NA AFP
Kim et al.[ 41 ] prospective Korea Jan 2007–Jun 2010 392 392 64 63.5 53.6 US, AFP, & US+AFP
Lersritwimanmaen and Nimanong[ 17 ] retrospective Thailand Jan 2012–Dec 2014 452 350 9 63.5 59.2 US & US+AFP
Lok et al.[ 18 ] case control USA 3.5 years (dates NA) 1031 116 39 71 50 US & AFP
Oka et al.[ 42 ] prospective Japan Jan 1983–Dec 1988 140 140 40 70 54.9 US & AFP
Paranagua‐ Vezozzo et al.[ 43 ] prospective Canada Aug 1998–Aug 2008 884 884 72 58.3 55 US & US+AFP
Pateron et al.[ 44 ] prospective France Jan 1986–Dec 1987 322 118 14 57.6 55 US & AFP
Paul et al.[ 45 ] prospective India Apr 2001–Nov 2014 301 301 107 88.3 45.1 US
Phulpoto et al. 2012[ 46 ] prospective Pakistan Apr 2008–Nov 2010 301 194 9 70 45.1 US
Pinero et al. 2014[ 11 ] retrospective Argentina Jun 2005–Dec 2011 643 643 56 70 59 US
Pocha et al.[ 47 ] prospective USA Jun 2002–Feb 2011 163 163 9 99.4 59.3 US
Qian et al.[ 48 ] retrospective Australia Oct 1998–Aug 2005 268 268 22 69.4 57.1 US, AFP, & US+AFP
Ren et al.[ 49 ] prospective USA Jun 1995–Jun 2005 6089 201 264 71 50 US & AFP
Sangiovanni et al.[ 50 ] prospective Italy 1985–1986 447 447 112 79 61 US & AFP
Sato et al.[ 51 ] retrospective Japan 1994–2004 1431 124 243 57 67 US & AFP
Singal et al.[ 52 ] prospective USA Jan 2004–Sep 2006 (2 years, 9 month) 446 446 41 58.6 52.8 US, AFP, & US+AFP
Sinn et al.[ 19 ] retrospective South Korea Jan 2008–Dec 2010 132 94 97 76.5 57.7 US, AFP, & US+AFP
Snowberger et al.[ 53 ] retrospective USA Jan 1988–Dec 2004 239 226 199 73.2 52.7 US & AFP
Solmi et al.[ 54 ] prospective Egypt Jan 1988–Dec 1993 360 254 24 67 52 US & AFP
Sterling et al.[ 55 ] retrospective Canada Jun 2000–Jun 2004 372 322 34 75 52.7 AFP
Tong et al.[ 56 ] prospective USA 1991–1998 602 173 31 51 59 US & AFP
Tong et al.[ 57 ] retrospective USA 1991–2008 78 63 68 82 56.5 US & US+AFP
Trevisani et al.[ 20 ] retrospective Italy Jan 1988–Dec 2001 1277 1037 184 NA NA AFP
Trinchet et al.[ 58 ] RCT France Jun 2000–Mar 2006 1340 1278 123 69.1 54.5 US
Ungrtukul et al.[ 59 ] prospective Thailand NA 2293 77 17 47 41.25 US & US+AFP
Ziada et al.[ 60 ] prospective Egypt Apr 2013–Jan 2015 514 NA 103 81 55.13 US & AFP
Zapata et al.[ 21 ] retrospective Spain 2003–2005 85 NA 85 87 63 US, AFP, & US+AFP
Zoli et al.[ 61 ] prospective Italy Jan 1989–Dec 1991 164 164 34 45.7 60 US & AFP

Abbreviations: AFP, alpha‐fetoprotein; HCC, hepatocellular carcinoma; NA, not applicable; US, ultrasound; US+AFP, ultrasound plus alpha‐fetoprotein.

a

Study reported median instead of mean age.