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. 2022 Jul 20;6(10):2732–2747. doi: 10.1002/hep4.2043

FIGURE 5.

FIGURE 5

Liver fibrosis outcomes differ between cAMP response element‐binding protein‐binding protein (CBP) and P300‐Alb/Cre KO mice on a DDC diet. Alb/Cre‐CBP‐KO, Alb/Cre‐P300KO, and control Alb/Cre male mice (8 weeks old, n = 15 per group) were fed a 0.1% DDC diet for 18 days. (A) Scheme of the treatment protocol. (B) HE, sirius red, and immunohistochemical staining for CK19 and Ki67 (scale bars, 250, 250, 500, 100, and 50 μm, respectively, from the top figure). (C) Quantification of CK19‐positive and Ki67‐positive in the liver. (D) Collagen deposition as assessed by hydroxyproline measurement. (E) mRNA expression of the indicated genes in the livers as determined by real‐time quantitative PCR (n = 10 per group). (F) Serum ALT, ALP, and T.Bil levels (n = 10–15 per group). The results shown are representative of at least three independent experiments. Data represent the mean ± SD; *p < 0.05, **p < 0.01, ***p < 0.005, and ****p < 0.0001 by one‐way ANOVA.