FIGURE 7.

AtRA reverses HFCF diet–induced obesity and hepatosteatosis dependent on hepatocyte RARα. Eight‐week‐old male Rara ^fl/fl mice and gL‐Rara ^−/− mice were fed an HFCF diet for a total of 20 weeks. After they were fed an HFCF diet for 10 weeks, they were also gavaged with vehicle or AtRA (15 mg/kg, once a day) for another 10 weeks. (A) Body weight over the 20 weeks was measured. (B,C) At the conclusion of the study, body weight (B) and body fat content (C) were also measured. (D) Hepatic TG levels were determined. (E,F) Representative liver images of Oil Red O staining (E) and H&E staining (F) are shown (scale bars = 20 μm). All values are expressed as mean ± SEM; *p < 0.05, **p < 0.01, ***p < 0.001.