Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 May 31;6(10):2613–2622. doi: 10.1002/hep4.2013

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 The Authors. Hepatology Communications published by Wiley Periodicals LLC on behalf of American Association for the Study of Liver Diseases.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

PMC Copyright notice

Proposed mechanisms through which GCKIII kinases control liver lipotoxicity. Silencing of MST3, MST4, or STK25 in human hepatocytes lowers fat storage by inhibiting lipid droplet anabolism through reduced triacylglycerol (TAG) synthesis, and by stimulating lipid droplet catabolism through enhanced β‐oxidation and very low–density lipoprotein (VLDL)–TAG secretion, resulting in protection against oxidative and endoplasmic reticulum (ER) stress. LD, lipid droplet. (Figure combines results from several publications (70, 71, 72, 73 and 75).