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. 2022 Jul 18;122(10):1683–1692. doi: 10.1055/s-0042-1749438

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The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ )

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.

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Fig. 2 — Class-wide lipidomic changes in COVID-19 and correlation with platelet reactivity. ( A ) Boxplots showing the median and interquartile ranges of PC and LPC subclasses. Each point shows the aggregated values per lipid class (a sum of all lipids per class) per subject, thus each point represents an individual. Values on the y -axis are semiquantitative lipid abundance (arbitrary unit, A.U). A p -value below 0.05 was considered significant after a Wilcoxon-ranked sum test. ( B ) Boxplots of LPG and BMP lipid classes. ( C ) Boxplots showing P-selectin expression (in MFI) on platelets in the basal state or after stimulation with TRAP, comparing patients with COVID-19 and matched controls. For both boxplots, a p -value below 0.05 was considered significant after a Wilcoxon-ranked sum test. * p -value < 0.05. ( D ) Scatterplots showing the correlation between aggregated LPG (left) and BMP (right) levels and platelet P-selectin expression (in MFI) after stimulation with TRAP. Values on the y -axis are semiquantitative lipid abundances (arbitrary unit, A.U). The strength of the correlation is depicted as Spearman's rho. ( E ) Same as in panel (D), but now split between controls and patients. BMP, bis(monoacylglycero)phosphate; LPC, lysophosphatidylcholine; LPG, lysophosphatidylglycerol; MFI, median fluorescence intensity; PC, phosphatidylcholine.