REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Phospho-AXL	Cell Signaling	RRID:mAb#5724
Phospho-MET	Cell Signaling	RRID:mAb#3077
Phospho-AKT	Cell Signaling	RRID:mAb#9271
Phospho-SRC	Cell Signaling	RRID:mAb#2101
AXL	Santa Cruz	RSC-166269
MET	Invitrogen	RRID:t 37-0100
AKT	Cell Signaling	RRID:mAb#9272
SRC	Cell Signaling	RRID:mAb#2109
Plk1	Abcam	RRID:ab17056
HSP90	Cell Signaling	RRID:mAb#4877
HSP60	Cell Signaling	RRID:mAb#12165
PARP	Cell Signaling	RRID:mAb#9532
anti-mouse CD31 (clone MEC 13.3)	BD Pharmingen	RRID:550274
Ki67 (clone MIB1)	DAKO	RRID:GA626
Biological samples
HNSCC samples at diagnosis and at relapse in parrafin	Human donors	Centre Antoine Lacassagne
HNSCC fresh biopsies	Human donors	Centre Antoine Lacassagne
Chemicals, peptides, and recombinant proteins
Cabozantinib (BMS-907351)	Selleckchem	Cat# S1119
Cisplatin	Mylar	Centre Antoine Lacassagne Pharmacy
Tricaine	Sigma-Aldrich	Cat# MS-222
Annexin V-APC	Biolegend	Cat#640941
Propidium Iodide	Biolegend	Cat#421301
ECL	Millipore	Cat#WBKL50500
FBS	Dutscher	Cat#S1810-500
GIEMSA	Sigma-Aldrich	Cat#GS1L-1L
Vybrant DiD cell-labeling solution	LifeTechnologies	Cat# V22887
Critical commercial assays
XTT (Cell Proliferation kit II)	Roche	Cat# 11465007001
Pierce™ BCA Protein Assay Kit	Thermo Fisher Scientific	Cat# 23225
QuantiTect Reverse Transcription Kit	Qiagen	Cat# 205311
SYBR Master Mix Plus	Eurogentec	Cat# UF-RSMT-B0701
In Situ Cell Death Detection Kit	Roche	Cat# 11684795910
ATP Bioluminescence Assay Kit HSII	Roche	Cat# 11699695001
Matrigel® Matrix	Corning	Cat# 356237
Collagen I	Corning	Cat# 354249
Deposited data
HNSCC patients - mRNA analysis	TCGA	www.cbioportal.org, TCGA HNSCC Firehose Legacy cohort38,39
Experimental models: Cell lines
CAL33	Centre Antoine Lacassagne, DSMZ	Cat# ACC 447
CAL27	Centre Antoine Lacassagne, ATCC	Cat# CRL-2095
Experimental models: Organisms/strains
Zebrafish embryos	Karolinska institute, Sweden	N/A
Rj:NMRI-Foxn1nu/Foxn1nu female mice	Janvier Labs, France	N/A
Oligonucleotides
AXL	Sigma-Aldrich	R-ATCTCTTGGTACTCAGATACTC
		F-CATGAAACATGGAGACCTAC
MET	Sigma-Aldrich	R-ATCTCTTCCCAGTGATAACC
		F- CATGTGAATTTTCTCCTGGAC
Software and algorithms
Prism 8.0	GraphPad	https://www.graphpad.com
ImageJ	Fiji	https://imagej.nih.gov/ij/
Other
DMEM high glucose GlutaMAX™ Supplement Pyruvate	Thermo Fisher Scientific	Cat# 31966-021
Penicillin streptomycin Gibco® Life Technologies	Thermo Fisher Scientific	Cat# 15140122
Normocure™	Invivogen	Cat# ant-noc
Airway Epithelial Cell Growth Medium	Promocell	Cat# C-21060
PVDF membrane	Millipore	Cat# T831.1
cell culture inserts with 8.0 μm pore transparent PET membrane	Corning, Falcon	Cat# 353097