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. 2022 Sep 12;3(9):100740. doi: 10.1016/j.xcrm.2022.100740

Figure 5.

Figure 5

[11C]-PIB and [18F]-FDG PET analysis of young adult SORL1 het and SORL1 wt Göttingen minipigs

Shown is [11C]-PIB- and [18F]-FDG PET analyses of four female 21-month-old SORL1 minipigs (het, 6469 and 6470; wt, 6475 and 6477).

(A) [11C]-PIB-PET summed images from the 30- to 90-min portion of the dynamic scan, divided by averaged whole brain activity.

(B) [18F]-FDG PET standard uptake volume (SUV) images, corrected for full brain activity.

(C) Absence of amyloid plaque pathology in a wt and a het SORL1 minipig (29 and 30 months old, respectively), as evidenced by lack of signals in immunostaining for deposits using an antibody for Aβ42 that is routinely applied in clinical settings for validation of AD pathology.

(D) Absence of fibrillar tangles in the wt and het SORL1 minipigs shown in (C), visualized by lack of signals in immunostaining with anti-tau phospho-Thr231 antibody, which is routinely applied in clinical settings for validation of AD pathology.