Figure 6.

Anatomical MRI analysis of young adult SORL1 het and SORL1 wt Göttingen minipigs

(A–F) Examples of 3D T2 FLAIR magnetic resonance images used for volume measurements (extracerebral tissue stripped for visualization) in female (6469) and male (6474) SORL1 het minipigs and female (6477) and male (338496) SORL1 wt minipigs (A). Also shown are quantification of whole brain volume (B), ventricle volume (C), amygdala width (D), entorhinal cortical thickness (E), and hippocampus volume (F) from anatomical MRI scanning. The four female minipigs (wt, 6475 and 6477; het, 6469 and 6470) and the four male minipigs (wt, 338496 and 338593; het, 6472 and 6474) were 22 and 27 months of age, respectively, when scanned. Data are expressed as mean ± SEM.