Figure 7.

Normal brain microstructure in SORL1 het and SORL1 wt Göttingen minipigs

(A) Examples of mean diffusivity (MD) and fractional anisotropy (FA) maps, representing tissue microstructure, from diffusion tensor MRI in female (6469) and male (6474) SORL1 het minipigs and female (6477) and male (338,496) SORL1 wt minipigs.

(B–E) FA and MD of the amygdala (B), hippocampus (C), corpus callosum (D), and deep white matter (E) were determined with DTI. The four female minipigs (wt, 6475 and 6477; het, 6469 and 6470) and the four male minipigs (wt, 338,496 and 338,593; het, 6472 and 6474) were 22 and 27 months of age, respectively, when scanned.

Data are expressed as mean ± SEM.