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. 2022 Sep 26;11(9):e1419. doi: 10.1002/cti2.1419

Figure 3.

Figure 3

Restoring autophagic flux improves the in vivo antitumor activity of senescent TCR‐Ts. (a) The flow diagram of the in vivo adoptive experiment using TCR‐Ts with and without spermidine treatment is shown. (b) The growth curves of tumors in PDX mice infused with TCR‐Ts with and without spermidine treatment are shown. Data represent mean ± SEM of n = 5 mice per group, one‐way ANOVA (Tukey's posttest). The results are representative of two independent experiments. (c, d) Representative flow cytometric plots indicating the infiltration of transferred untreated TCR‐Ts or spermidine‐treated TCR‐Ts in tumors from PDX mice is shown on day 12 after tumor implantation (c). A statistical summary of counts of transferred TCR‐T cells per g tumor is shown (d). Data represent mean ± SEM of n = 3 biological replicates, the t‐test. *P < 0.05, **P < 0.01, ***P < 0.001.