Extended Data Fig. 7. Reduced χ2 surfaces obtained from constrained parameter optimization and distribution of fit parameters obtained from Monte Carlo trials: simulations for 19F and 13C RD data.
(A) One dimensional reduced χ2 surfaces for the simultaneous analysis of 13C CPMG, 19F CPMG and 19F R1ρ relaxation data. Reduced χ2 values were obtained as a function of the exchange rate and the ground state population after optimization of all remaining free parameters. (B) Distribution of fit parameters obtained from MC simulations, where 13C CPMG, 19F CPMG and 19F R1ρ relaxation data were fitted simultaneously. The extracted fitting parameters, including errors are summarized in Supplementary Table 6.