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First line options which are considered standard of care
| Recommendations | Level of Evidence (LoE) | Grade of recommendation | Grade of consensus |
|---|---|---|---|
| Offer axitinib + pembrolizumab to treatment-naïve patients with any IMDC-risk category | 1 − | A | Strong |
| Physicians may offer axitinib + avelumab to treatment-naïve patients with any IMDC-risk category | 1 − | B | Consensus |
| Offer ipilimumab + nivolumab to treatment-naïve patients with intermediate or poor IMDC-risk category | 1 − | A | Strong |
