Table 4.
Cox proportional hazards regression analysis with imputation by multiple chained equations of predictive factors for genitourinary toxicity-related admission following primary prostate EBRT
| Characteristic | N | Univariable regression | Multivariable regression | ||||
|---|---|---|---|---|---|---|---|
| HR | 95% CI | p value | HR | 95% CI | p value | ||
| Age, years | 3243 | 1.01 | 1.00, 1.03 | 0.010 | 1.01 | 1.00, 1.02 | 0.2 |
| Charlson Score | 3243 | 1.06 | 0.99, 1.12 | 0.091 | |||
| Diabetes | 3243 | 1.54 | 1.29, 1.82 | < 0.001 | 1.28 | 1.08, 1.53 | 0.004 |
| Obesity | 3243 | 1.56 | 0.99, 2.46 | 0.076 | |||
| Hypertension | 3243 | 4.74 | 1.18, 19.0 | 0.080 | |||
| Tumour stage | 3243 | 1.00 | 0.79, 1.26 | > 0.9 | |||
| Gleason score | 3243 | 1.03 | 0.96, 1.10 | 0.5 | |||
| PSA | 3243 | 1.00 | 1.00, 1.00 | 0.2 | |||
| Smoking | 3243 | 2.73 | 2.30, 3.23 | < 0.001 | 1.67 | 1.40, 2.00 | < 0.001 |
| Anticoagulation | 3243 | 1.96 | 1.60, 2.40 | < 0.001 | |||
| Urinary incontinence | 3243 | 7.82 | 6.60, 9.27 | < 0.001 | 3.95 | 3.28, 4.75 | < 0.001 |
| BOO and TURP.c | 3243 | 3.58 | 3.02, 4.25 | < 0.001 | 3.67 | 3.01, 4.46 | < 0.001 |
| BOO no TURP | 3243 | 6.07 | 5.10, 7.23 | < 0.001 | 5.87 | 4.80, 7.17 | < 0.001 |
| No BOO no TURP | 3243 | 0.15 | 0.13, 0.17 | < 0.001 | |||
| EBRT before 2009 | 3243 | 1.24 | 1.04, 1.47 | 0.016 | 0.87 | 0.72, 1.04 | 0.12 |
| Dose, Gy | 3243 | 1.00 | 0.99, 1.02 | 0.4 | |||
Any statistically significant p-values were bolded
HR, Hazard ratio; CI, confidence interval; PSA, Prostate specific antigen; BOO, Bladder Outlet Obstruction; TURP, Transurethral Resection of Prostate; EBRT, External beam radiotherapy; Gy, Gray