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. 2022 Sep 26;13:5636. doi: 10.1038/s41467-022-33277-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Superposition of the METTL4 with METTL3-METTL14 heterodimer. b Close-up view of the catalytic pocket formed by the four loops in the MTase domains of METTL4 and METTL3, and the key residues were shown as sticks. c Structural superposition of METTL4 and METTL3 shows the Gate Loop2 makes clashes with Am. d The NTD makes interaction with Gate Loop2 of MTase domain. e Modeled catalytic center of METTL4 by replacing SAH with SAM. f Structural superposition of the catalytic center of METTL4 and METTL3.