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. 2022 Sep 26;13:5636. doi: 10.1038/s41467-022-33277-x

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Fig. 5 — Diagrammatic presentation of the catalytic mechanism of METTL4. In the initial step (1) the backbone phosphate of Am may be bound by H321 in interface loop; then, Y247 in the Gate Loop1 interacts with N⁶ of Am (2), followed by hydrogen binding from D233 and P234 and methyl group transferred from SAM to N⁶ of Am (3). Finally, N⁶-methylated Am is released from the pocket due to the steric clash (4).