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. 2022 Sep 26;13:5632. doi: 10.1038/s41467-022-33290-0

Fig. 2. In vitro anticancer drug screen.

Fig. 2

a Volcano plots showing differences in IC50 values between RAS high and low CCLE cell lines. Drugs with enriched target annotations in the significant sensitive and resistant groups are highlighted (hypergeometric test) Drugs with an absolute log2 fold change >1 and fdr < 0.05 (linear model with Benjamini-Hochberg correction) are shown in dark grey. Results from both GDSC1 & 2 are shown. b Drug target annotation enrichment in sensitive and resistant drugs from GDSC1 & 2 (fdr < 0.05) in the RAS high CCLE cell lines, determined by hypergeometric test with Benjamini–Hochberg correction. Target terms enriched in the sensitive drugs are shown in blue, the resistant in red. The number of drugs in each group is indicated by the size of the point. All tested targets are shown. c, d Volcano plots showing differences in IC50 values between KRAS mutant and wild-type cell lines and RAS pathway mutated and wild-type cell lines (linear model with Benjamini–Hochberg correction). Drugs with enriched target annotations in the significant sensitive and resistant groups are highlighted (hypergeometric test).