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. 2022 Sep 26;13:5632. doi: 10.1038/s41467-022-33290-0

Fig. 5. RAS84 predicts survival in lung adenocarcinoma.

Fig. 5

a–d Kaplan–Meier plots showing overall survival data from the TCGA LUAD cohort for patients stratified by KRAS mutation (coxph p-value 0.23) (a) or from RAG-4 and RAG-0 (coxph p-value 0.0001) (b), progression-free survival data from the TCGA LUAD cohort for patients from RAG-4 and RAG-0 (coxph p-value 0.0017) (c) and a Cox proportional hazards regression fit of TCGA LUAD survival data to RI values. The grey survival curve shows the observed data. The blue survival curve is the predicted survival if the RI values decreased 2-fold. The red curve is the predicted survival values if the RI were to increase 2-fold (coxph p-value 0.0004) (d), Patient number is indicated between brackets. e Forest plot showing results from a multivariate Cox proportional hazards analysis of the Uppsala lung adenocarcinoma cohort (n  =  103 patients). Hazard ratios and 5 and 95% confidence intervals are shown on a natural log scale. f–h Kaplan–Meier plots showing overall survival data from the Uppsala cohort for patients from RAG-4 and RAG-0 (multivariate coxph p-value 0.0088) (f), RAG-3 and RAG-0 (multivariate coxph p-value 0.024) (g) and a Cox proportional hazards regression fit of Uppsala survival data to RI values. The grey survival curve shows the observed data. The blue survival curve is the predicted survival if the RI values decreased 2-fold. The red curve is the predicted survival values if the RI were to increase 2-fold (coxph p-value 0.036) (h). i Multivariate p-values and hazard ratios plotted for Uppsala RAGs clusters derived from the published signatures. The p-values are plotted on a −log10 scale (coxph p-value RAS84 RAG-4 0.0088, RAS84 RAG-3 0.024). j Forest plot showing results from a multivariate Cox proportional hazards analysis of PFS after chemotherapy in the TEMPUS lung adenocarcinoma cohort (n  =  100 patients) (coxph p-value RAG-high p-value 0.0018). Hazard ratios and 5 and 95% confidence intervals are shown on a natural log scale. k Multivariate p-values and hazard ratios plotted for TEMPUS RAGs and clusters derived from the published signatures. The p-values are plotted on a −log10 scale.