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. 2022 Mar 18;12(11):2865–2874. doi: 10.1007/s13346-022-01150-5

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Schematic representation of the different prototypes of NCs and composition of the non-isolated samples. SD, solvent displacement; SE, self-emulsifying; l-PEG, polyethylene glycol (PEG) present in a linear disposition in the main surfactant; b-PEG, branched-disposed PEG on the main surfactant; noPEG, no PEGylated components. Polymers: HA, hyaluronic acid; PSA, polysialic acid; PEG·PGA, polyethylene glycol polyglutamic acid. PEGylated surfactants: TPGS, d-α-tocopherol polyethylene glycol 1000 succinate; Kol. HS15, Kolliphor® HS15, Tween® 80. Non-PEGylated surfactants: BZT, benzethonium; CTAB, hexadecyltrimethylammonium; DOTAP, 1,2-dioleoyl-3-trimethylammoniumpropane, lecithin. Oils: C₈/C₁₀ TGs, caprylic and capric acid triglycerides, α-tocopherol. The disposition of the components on the NC was assumed based on their physicochemical properties, mainly hydrophobicity and charge