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. 2022 Sep 17;17(5):517–527. doi: 10.1007/s11523-022-00906-w
Patients with intrahepatic cholangiocarcinoma and fibroblast growth factor receptor (FGFR)-2 alterations appear to have longer overall survival and longer progression-free survival on second-line systemic therapy compared with patients without FGFR alterations.
The apparent advantage in progression-free survival during second-line systemic therapy in patients with intrahepatic cholangiocarcinoma and FGFR2 alterations may have an implication to the value of first-line chemotherapy.