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. 2022 Sep 26;5:1009. doi: 10.1038/s42003-022-03906-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Volcano plots showing the differentially methylated cytosines (DMC) with the change of DNA methylation larger than 20% and p value smaller than 0.05 in aversive a, or appetitive b, vCA1 cells compared to the neutral group. DMCs in different genomic positions (3’UTR, 5’UTR, exon, intergenic, intron, non-coding promotor, TSS) are color coded. Volcano plot showing differently methylated regions (DMRs) that contain at least two DMCs for each DMR in aversive c, and appetitive d, vCA1 cells. The top 10 hypermethylated and hypomethylated regions were highlighted in either pink or blue separately and were annotated to its nearest genes. e A Venn diagram showing differently methylated genes (DMGs) that are associated with DMRs in c and d identified in aversive and appetitive vCA1 cells. f, GO analysis of DMGs in aversive vCA1 cells. g GO analysis of DMGs in appetitive vCA1 cells.