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. 2022 Sep 26;13:5657. doi: 10.1038/s41467-022-33410-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Venn diagram of up-regulated BP terms in DNMT3A-mutant AML cells from both AML patients (TCGA: DNMT3A^mut, n = 36; DNMT3A^wt, n = 115) and AML cell lines (CCLE: DNMT3A^mut, n = 4; DNMT3A^wt, n = 30). b Survival curves of AML patients with high and low expression designated gene set, and n is the number of biologically independent samples. The survival analysis was performed by the log-rank (Mantel–Cox) test. c Cell adhesion assay for human AML cells seeded on fibronectin or collagen. n = 3 biologically independent experiments. d Cell-cell adhesion between human AML cells and HUVECs. e Representative flow cytometry results for cell-cell adhesion between human AML cells and HUVECs. f Representative fluorescent image for cell-cell adhesion between human AML cells and HUVECs. Scale bar, 50 μm. g Statistical results for cell-cell adhesion between human AML cells and HUVECs. n = 3 biologically independent experiments. The data were shown as the mean ± SD. Statistical significance was tested with One-way ANOVA. Source data are provided as a Source Data file.