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. 2022 Sep 26;13:5657. doi: 10.1038/s41467-022-33410-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Cell viability assay of OCI-AML2 and OCI-AML3 treated with different carbon-based nanomaterials for 24 h. n = 3 biologically independent experiments. b Schematic illustration showing the structures of GDYO and GO. Carbon and oxygen atoms were shown in blue and red respectively. c C 1 s spectra of XPS scan for GDYO. d Cell viability assay of DNMT3A-mutant AML cell lines (OCI-AML2, OCI-AML3) and DNMT3A wildtype AML cell lines (HL-60, THP-1) treated with GO or GDYO at different concentrations for 24 h. n = 3 biologically independent experiments. e Apoptotic rates in OCI-AML3 and HL-60 treated with 20 μg/mL GO/GDYO for 48 h. n = 3 biologically independent experiments. f Cell adhesion assay on fibronectin for OCI-AML3 and HL-60 treated with 20 μg/mL GO/GDYO for 24 h. n = 3 biologically independent experiments. g Wright-Giemsa staining showing signs of maturation in GDYO-treated OCI-AML3. Scale bar, 20 μm. h–i Flow cytometry analysis of leukemic progenitor cells and leukemic stem cells in OCI-AML3 and HL-60 treated with 20 μg/mL GO/GDYO for 72 h. n = 3 biologically independent experiments. The data were shown as the mean ± SD. Statistical significance was tested with a two-tailed, unpaired Student’s t test. Source data are provided as a Source Data file.