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. 2022 Sep 26;13:5657. doi: 10.1038/s41467-022-33410-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Schematic illustration of the experimental design. b Representative IVIS spectrum images. n = 5 biologically independent animals. c Kaplan-Meier survival curve of AML mice injected with saline or GDYO. n = 8 biologically independent animals. d Spleen weight of AML mice injected with saline or GDYO at sacrifice. n = 6 biologically independent animals. e Bone marrow H&E sections of AML mice injected with saline or GDYO at sacrifice. Scale bar, 100 μm. f Representative flow cytometry images of BM total mononuclear cells. g-i Absolute number of leukemia cells (g) and absolute number of leukemia stem cells (h) in BM from AML mice injected with saline or GDYO. n = 6 biologically independent animals. i Myeloid differentiation (CD11b⁺/CD14⁺) of BM leukemia cells from AML mice injected with saline or GDYO. n = 6 biologically independent animals. j Illustration for GDYO therapy against DNMT3A-mutant AML cell. The data were shown as the mean ± SD. Statistical significance was tested with a two-tailed, unpaired Student’s t test. Source data are provided as a Source Data file.