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. 2022 Sep 27;65(3):311–325. doi: 10.1007/s12033-022-00567-0

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Fig. 7 — Schematic illustration of CRISPR/Cas13b mechanism. Cas13b protein is associated with the mature crRNA. This ÇRISPR/Cas13b complex searches for the target ssRNA and induces precise conformational changes at the ssRNA target with the help of the Protospacer flanking site (PFS), which flanks RNA targeting at the 5′ end and PAM sequence (NAN/NNA) at the 3′ end, resulting in nonspecific RNA cleavage