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. 2022 Sep 26;13:5654. doi: 10.1038/s41467-022-32867-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — IgG-Fc core fucosylation levels of SARS-CoV-2–specific IgG in critically (red bars), severely (blue bars) and mildly (grey bars) diseased COVID-19 patients. Analysis was carried out on a pool of 5 different sera. Measured OD values (fucosylation) of the generated eluates were normalized to their respective IgG concentrations determined by antigen-specific S1 and N ELISA. a S-IgG-Fc-fucosylation and b N-IgG-Fc-fucosylation in critically and severely diseased patients characterized by either high (red) or low (patterned) CD16A-activation levels in the FcγRIIIA/CD16A reporter assay. Of note, for mildly diseased patients only sera displaying low CD16 activation levels were available and analyzed respectively. The mean and standard deviation (SD) of three independent experiments is depicted. Each dot represents one individual experiment. Statistical tests using a two-factorial linear model (one-sided, no adjustments) indicate three significant differences between the low and high categories as well as between patients of the different groups (^***p < 0.001, ^**p < 0.01, ^*p < 0.05). n.a.: not available. Source data are provided as a Source Data file.