Table 5.
Event, n (%) | T+S (n=43) | T+S+ICIs (n=33) | p value | ||||||
---|---|---|---|---|---|---|---|---|---|
Any grade | Grade 1/2 | Grade 3/4 | Any grade | Grade 1/2 | Grade 3/4 | Any grade | Grade 1/2 | Grade 3/4 | |
Any TRAE | 40(93.0) | 37(86.0) | 6(14.0) | 33(100.0) | 29(87.9) | 7(21.2) | 0.122 | 0.815 | 0.405 |
Fatigue | 14(32.6) | 10(23.3) | 4(9.3) | 15(45.5) | 10(30.3) | 5(15.2) | 0.251 | 0.489 | 0.434 |
Decreased appetite | 12(27.9) | 9(20.9) | 3(7.0) | 15(45.5) | 11(33.3) | 4(12.1) | 0.113 | 0.224 | 0.442 |
Vomiting or nausea | 14(32.6) | 12(27.9) | 2(4.7) | 11(33.3) | 9(27.3) | 2(6.1) | 0.943 | 0.951 | 0.785 |
Abdominal pain | 12(27.9) | 11(25.6) | 1(2.3) | 10(30.3) | 9(27.3) | 1(3.0) | 0.819 | 0.868 | 0.849 |
Fever | 13(30.2) | 10(23.3) | 3(7.0) | 13(39.4) | 11(33.3) | 2(6.1) | 0.404 | 0.330 | 0.873 |
Dose reduce or interruptions | 5(11.6) | 4(9.3) | 1(2.3) | 7(21.2) | 4(21.1) | 3(9.1) | 0.256 | 0.691 | 0.190 |
Hypertension | 3(7.0) | 2(4.7) | 1(2.3) | 5(15.2) | 3(9.1) | 2(6.1) | 0.250 | 0.439 | 0.407 |
Hand and foot syndrome | 8(18.6) | 6(14.0) | 2(4.7) | 8(24.2) | 5(15.2) | 3(9.1) | 0.550 | 0.883 | 0.439 |
Diarrhea | 2(4.7) | 2(4.7) | 0(0.0) | 4(12.1) | 4(12.1) | 0(0.0) | 0.231 | 0.231 | _ |
Alopecia | 3(7.0) | 3(7.0) | 0(0.0) | 2(6.1) | 2(6.1) | 0(0.0) | 0.873 | 0.873 | _ |
Pruritus | 5(11.6) | 5(11.6) | 0(0.0) | 6(18.2) | 5(15.2) | 1(3.0) | 0.421 | 0.652 | 0.251 |
Rash | 1(2.3) | 1(2.3) | 0(0.0) | 4(12.1) | 3(9.1) | 1(3.0) | 0.088 | 0.190 | 0.251 |
Proteinuria Increased AST |
8(18.6) 7(16.3) |
6(14.0) 6(14.0) |
2(4.7) 1(2.3) |
12(36.4) 8(24.2) |
9(27.3) 6(18.2) |
3(9.1) 2(6.1) |
0.081 0.387 |
0.148 0.616 |
0.439 0.407 |
Increased ALT | 6(14.0) | 4(9.3) | 2(4.7) | 8(24.2) | 6(18.2) | 2(6.1) | 0.251 | 0.256 | 0.785 |
Decreased neutrophil count | 6(14.0) | 6(14.0) | 0(0.0) | 6(18.2) | 6(18.2) | 0(0.0) | 0.616 | 0.616 | – |
Increased blood bilirubin | 6(14.0) | 6(14.0) | 0(0.0) | 8(24.2) | 7(21.2) | 1(3.0) | 0.251 | 0.405 | 0.251 |
Gastrointestinal hemorrhage | 3(7.0) | 3(7.0) | 0(0.0) | 2(6.1) | 2(6.1) | 0(0.0) | 0.873 | 0.873 | – |
Hypothyroidism | 0(0.0) | 0(0.0) | 0(0.0) | 3(9.1) | 3(9.1) | 0(0.0) | 0.044 | 0.044 | – |
RCCEP | 0(0.0) | 0(0.0) | 0(0.0) | 10(30.3) | 10(30.3) | 0(0.0) | <0.001 | <0.001 | – |
Data are numbers of patients, with percentages in parentheses. TACE, transarterial chemoembolization; ICIs, immune checkpoint inhibitors; AST, aspartate aminotransferase; ALT, alanine transaminase; RCCEP, reactive cutaneous capillary endothelial proliferation.