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. 2022 Sep 13;12:914385. doi: 10.3389/fonc.2022.914385

Table 5.

Treatment-related adverse events (TRAE).

Event, n (%) T+S (n=43) T+S+ICIs (n=33) p value
Any grade Grade 1/2 Grade 3/4 Any grade Grade 1/2 Grade 3/4 Any grade Grade 1/2 Grade 3/4
Any TRAE 40(93.0) 37(86.0) 6(14.0) 33(100.0) 29(87.9) 7(21.2) 0.122 0.815 0.405
Fatigue 14(32.6) 10(23.3) 4(9.3) 15(45.5) 10(30.3) 5(15.2) 0.251 0.489 0.434
Decreased appetite 12(27.9) 9(20.9) 3(7.0) 15(45.5) 11(33.3) 4(12.1) 0.113 0.224 0.442
Vomiting or nausea 14(32.6) 12(27.9) 2(4.7) 11(33.3) 9(27.3) 2(6.1) 0.943 0.951 0.785
Abdominal pain 12(27.9) 11(25.6) 1(2.3) 10(30.3) 9(27.3) 1(3.0) 0.819 0.868 0.849
Fever 13(30.2) 10(23.3) 3(7.0) 13(39.4) 11(33.3) 2(6.1) 0.404 0.330 0.873
Dose reduce or interruptions 5(11.6) 4(9.3) 1(2.3) 7(21.2) 4(21.1) 3(9.1) 0.256 0.691 0.190
Hypertension 3(7.0) 2(4.7) 1(2.3) 5(15.2) 3(9.1) 2(6.1) 0.250 0.439 0.407
Hand and foot syndrome 8(18.6) 6(14.0) 2(4.7) 8(24.2) 5(15.2) 3(9.1) 0.550 0.883 0.439
Diarrhea 2(4.7) 2(4.7) 0(0.0) 4(12.1) 4(12.1) 0(0.0) 0.231 0.231 _
Alopecia 3(7.0) 3(7.0) 0(0.0) 2(6.1) 2(6.1) 0(0.0) 0.873 0.873 _
Pruritus 5(11.6) 5(11.6) 0(0.0) 6(18.2) 5(15.2) 1(3.0) 0.421 0.652 0.251
Rash 1(2.3) 1(2.3) 0(0.0) 4(12.1) 3(9.1) 1(3.0) 0.088 0.190 0.251
Proteinuria
Increased AST
8(18.6)
7(16.3)
6(14.0)
6(14.0)
2(4.7)
1(2.3)
12(36.4)
8(24.2)
9(27.3)
6(18.2)
3(9.1)
2(6.1)
0.081
0.387
0.148
0.616
0.439
0.407
Increased ALT 6(14.0) 4(9.3) 2(4.7) 8(24.2) 6(18.2) 2(6.1) 0.251 0.256 0.785
Decreased neutrophil count 6(14.0) 6(14.0) 0(0.0) 6(18.2) 6(18.2) 0(0.0) 0.616 0.616
Increased blood bilirubin 6(14.0) 6(14.0) 0(0.0) 8(24.2) 7(21.2) 1(3.0) 0.251 0.405 0.251
Gastrointestinal hemorrhage 3(7.0) 3(7.0) 0(0.0) 2(6.1) 2(6.1) 0(0.0) 0.873 0.873
Hypothyroidism 0(0.0) 0(0.0) 0(0.0) 3(9.1) 3(9.1) 0(0.0) 0.044 0.044
RCCEP 0(0.0) 0(0.0) 0(0.0) 10(30.3) 10(30.3) 0(0.0) <0.001 <0.001

Data are numbers of patients, with percentages in parentheses. TACE, transarterial chemoembolization; ICIs, immune checkpoint inhibitors; AST, aspartate aminotransferase; ALT, alanine transaminase; RCCEP, reactive cutaneous capillary endothelial proliferation.