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. 2022 Sep 13;9:881181. doi: 10.3389/fcvm.2022.881181

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Copyright © 2022 Nishimoto, Sata and Fukuda.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inflammation caused by STING. STING recognizes cGAMP, which originates from DNA fragments. Not only DNA fragments derived from pathogens, but also endogenous DNA fragments can activate STING signaling, promoting inflammatory responses. This figure is reproduced from Fukuda et al. (80) with modification.