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. 2022 Sep 13;9:881181. doi: 10.3389/fcvm.2022.881181

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Copyright © 2022 Nishimoto, Sata and Fukuda.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DNA sensing system and lifestyle-related diseases. Endogenous DNA fragments activate the DNA sensing mechanism, which participates in the activation of the immune response. Immune response caused by endogenous DNA fragments via DNA sensors such as TLR9 and STING accelerates sterile inflammation, leading to the development of lifestyle-related diseases, such as atherosclerosis, metabolic diseases, and pulmonary diseases.