TABLE 1.

Scaffold proteins that have been reported to be associated with neurological or psychiatric disorders from human genetics studies.

Genes	Reported disorders and references
SHANK1	Autism (Sato et al., 2012)
SHANK2	Autism, ID (intellectual disability) (Berkel et al., 2010; Satterstrom et al., 2020)
SHANK3	Autism (Durand et al., 2007; Moessner et al., 2007; Satterstrom et al., 2020)
SYNGAP1	ID (Intellectual disability) (Hamdan et al., 2009; Rauch et al., 2012; Deciphering Developmental Disorders Study., 2015, 2017), autism (Hamdan et al., 2011; Satterstrom et al., 2020)
GRIP1	Autism (Mejias et al., 2011)
HOMER1	Autism (Kelleher<suffix>III</suffix>, Geigenmuller et al., 2012), schizophrenia (Norton et al., 2003), depression (Rao et al., 2016)
PSD95	Schizophrenia, ID, autism (Coley and Gao, 2018)
CASK	ID (Hayashi et al., 2008; Najm et al., 2008), brain malformation (Najm et al., 2008)
PICCOLO	Major depressive disorder (Sullivan et al., 2009), bipolar disorder (Choi et al., 2011; Chen et al., 2021), schizophrenia (Chen et al., 2021)
BASSOON	Bipolar disorder, schizophrenia (Chen et al., 2021)
STXBP1/MUNC18-1	Dravet Syndrome (Carvill et al., 2014), Infantile epileptic encephalopathy (Saitsu et al., 2008)