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. 2022 Sep 13;13:941556. doi: 10.3389/fimmu.2022.941556

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Copyright © 2022 Ji, Liu, Wang, Sun, Wang, Liu, Hu and You

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immune characteristics of MRGPI groups. (A) The fraction of immune infiltration was estimated by CIBERSORT. (B) GSEA analysis of pathways enriched in each group based on the expression profile of the Mono/Macro subcluster. Pathways with FDR-q < 0.1 were exhibited. The color (red or blue) was proportional to the NES of the corresponding pathway in MRGPI-high or -low groups. (C) The expression of macrophage biomarkers in MRGPI-based groups. Mono/Macro subcluster was split into -high, -medium, and -low groups by the MRGPI. (D) Correlation between the MRGPI and different macrophages at the bulk-tumor level. *p < 0.05, **p < 0.01, ***p < 0.001. ns, non significant.