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. 2022 Sep 13;13:941556. doi: 10.3389/fimmu.2022.941556

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Copyright © 2022 Ji, Liu, Wang, Sun, Wang, Liu, Hu and You

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression of immune checkpoints associated with MRGPI. (A) The expression of PD-L1/2, TIM3, and CTLA-4 based on the TCGA cohort. (B) Multivariate regression analysis estimating the association between the expression of immune checkpoints and M2 macrophage faction. (C) Association between MRGPI and expression of PD-L2 and TIM3 on a pan-cancer scale. ACC and UVM that had sterile lymphocyte infiltration and LUAD and LUSC that had abundant lymphocyte infiltration were used as references. ACC, Adrenocortical carcinoma; UVM, Uveal Melanoma; LUAD, Lung adenocarcinoma; LUSC, Lung squamous cell carcinoma. (D) The expression of PD-L1/2 and TIM3 at a single-cell resolution based on GSE70630.