Skip to main content
. 2022 Sep 13;3:932530. doi: 10.3389/fpain.2022.932530

Figure 2.

Figure 2

Myelin oligodendrocyte glycoprotein (MOG) in Sprague-Dawley (SD) rats produces full mechanical allodynia at all doses tested. Sprague-Dawley (SD) rats were baselined (BL) for mechanical withdrawal thresholds via the von Frey test, followed by intradermal low-dose (0, 4, 8, and 16 μg) myelin oligodendrocyte glycoprotein (MOG). Allodynia was assessed thereafter across the timecourse shown, continuing through day 30. All doses of MOG induced full mechanical allodynia by day 15, which lasted through day 29. Main effects of day [F(4, 64) = 161.3; p < 0.0001], MOG dose [F(3, 16) = 29.83; p < 0.0001], and interaction between day and MOG dose [F(12, 64) = 10.8; p < 0.0001]. N = 5/group. Post-hocs: **** indicates significant differences between 0 μg MOG control and 4 μg MOG, #### indicates significant differences between 0 μg MOG control and 8 μg MOG, ∧∧∧∧ indicates significant differences between 0 μg MOG control and 16 μg MOG.