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. 2022 Sep 13;3:932530. doi: 10.3389/fpain.2022.932530

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Copyright © 2022 Kwilasz, Clements, Larson, Harris, Litwiler, Woodall, Todd, Schrama, Mitten, Maier, Van Dam, Rice and Watkins.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Daily systemic administration of the TLR2–TLR4 antagonist (+)-Naltrexone [(+)-NTX] does not alter EAE motor scores in Sprague-Dawley (SD) rats. Sprague-Dawley (SD) rats were baselined (BL) for motor scores followed by intradermal low-dose (0, 8, and 16 μg) myelin oligodendrocyte glycoprotein (MOG). (+)-NTX [6 mg/kg subcutaneously (SC) 3x/day] vs. saline was initiated on day 17 post-MOG, continuing through day 30 (see gray rectangle indicating span of drug delivery), and motor scores were assessed thereafter across the timecourse shown. (A,B) No dose of MOG reliably increased motor scores. (+)-NTX did not alter motor scores. N = 8/group.