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. 2022 Sep 13;3:932530. doi: 10.3389/fpain.2022.932530

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Copyright © 2022 Kwilasz, Clements, Larson, Harris, Litwiler, Woodall, Todd, Schrama, Mitten, Maier, Van Dam, Rice and Watkins.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Myelin oligodendrocyte glycoprotein (MOG) does not induce lumbar spinal cord dorsal horn or ventral funiculus CD4 immunoreactivity. Sprague-Dawley (SD) from Experiment 2 received intradermal low-dose (0, 8, and 16 μg) myelin oligodendrocyte glycoprotein (MOG). Spinal cord tissue was collected on day 30 post-MOG administration and during 13 days of daily (+)-NTX administration. Neither dose of MOG increased expression of the T cell immunoreactivity marker CD4 in either dorsal horn (A) or ventral funiculus (B) of lumbar spinal cord. (+)-NTX administration also did not alter CD4 immunoreactivity in either region. N = 5–8/group with 2–4 pictures analyzed per subject.