Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Sep 13;9:947203. doi: 10.3389/fmolb.2022.947203

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Muthelo, Mulaudzi, Netshishivhe, Dongola, Kok, Makumire, de Villiers, Burger, Zininga and Shonhai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Proposed model of PES binding PfHsp70-1. The schematic represents a model for the mechanism of action of PES. The model suggests that PES binds to both PfHsp70-1 and PfHop thereby perturbing the conformations of the two proteins. Consequently, this abrogate the chaperone function of PfHsp70-1 and their interaction. The inhibition of the interaction of PfHsp70-1 and PfHop adversely impacts on the functional partnership between PfHsp70-1 and PfHsp90.