Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Sep 13;9:947203. doi: 10.3389/fmolb.2022.947203

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Muthelo, Mulaudzi, Netshishivhe, Dongola, Kok, Makumire, de Villiers, Burger, Zininga and Shonhai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Schematic representing the interaction of PES with PfHop. (A) A docked three-dimensional model with a ribbon structure of full-length PfHop bound to PES. The domains of the protein are also shown. PES binds to the TPR1, DP1, and TPR2B regions of the protein. (B) Surface and ribbon views of the docked structures, showing the residues involved in the interaction. (C) A 2D illustration of the receptor-ligand interface. PES appears to hydrogen bond with residues Arg407 on PfHop. Thus, PES forms pi-pi T-shaped interactions with Tyr372, pi-alkyl with Leu124 and Ile373, pi sigma, and pi-sulfur with Met123 of PfHop.