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PES inhibits the direct association of PfHsp70-1 and PfHop.
| Ligand | Analyte | Name of the inhibitor | IC50 (nM) |
|---|---|---|---|
| PfHsp70-1 | PfHop | EGCG | 13.90 ± 1.2 |
| PES | 32.43 ± 2.1 | ||
| PfHop | PfHsp70-1 | EGCG | 14.57 ± 1.8 |
| PES | 38.13 ± 3.6 |
Interaction of PfHsp70-1 and PfHop was investigated using ELISA, with analyte and ligand alternating. IC50 values for the interaction of the proteins in the presence of PES and EGCG (control) are shown.
