Table 2.
Summary of organoid-based clinical trails
| Application | Condition or disease | Research title | ClinicalTrials.gov Identifier |
|---|---|---|---|
| Drug Screening | Pancreatic Cancer | A Prospective, Randomized, Controlled Trial of Chemotherapy for Advanced Pancreatic Cancer Based on Organoid Drug Sensitivity Test | NCT04931381 |
| Guidance of Standard of Care Treatment for Metastatic Pancreatic Cancer by Drug Screening in Patient-derived Organoids: A Single Centre, Open-label, Single Arm, Phase II Trial With Feasibility Endpoint | NCT05351983 | ||
| A Prospective, Randomized, Controlled Trial of Adjuvant Chemotherapy for Pancreatic Cancer Based on Organoid Drug Sensitivity Test | NCT04931394 | ||
| Drug Screening of Pancreatic Cancer Organoids Developed From EUS-FNA Guided Biopsy Tissues | NCT03544255 | ||
| Pharmacotyping of Patient-derived Pancreatic Cancer Organoids from Endoscopic Ultrasound-guided Biopsy as a Tool for Predicting Oncological Response | NCT05196334 | ||
| Colorectal Cancer | Prospective Observation on the Accuracy of in Vitro Screening of Colorectal Cancer Chemotherapy Drugs Based on Organoids-on-a-chip | NCT04996355 | |
| Patient-derived Organoids of RAS/RAF Wild-type Metastatic Right Colon Cancer to Test the Sensitivity and Clinical Consistency of Combined Treatment of Cetuximab. | NCT04906733 | ||
| A Prospective Multicenter Randomized Controlled Trial of the Clinical Efficacy of Neoadjuvant Therapy Based on Organoids Drug Sensitivity Versus Empirical Neoadjuvant Therapy in the Treatment of Advanced Rectal Cancer | NCT05352165 | ||
| The Culture of Advanced/Recurrent/Metastatic Colorectal Cancer Organoids and Drug Screening | NCT05304741 | ||
| Pilot Study for Ex Vivo Tailoring of Treatment in Colorectal Cancer | NCT05401318 | ||
| Gastric Cancer | The Clinical Efficacy of Patient-derived Organoid-based Drug Sensitive Neoadjuvant Chemotherapy Versus Traditional Neoadjuvant Chemotherapy in Advanced Gastric Cancer: A Prospective Multi-center Randomized Controlled Study | NCT05351398 | |
| Consistency Between Treatment Responses in Patient-Derived Organoid (PDO) Models and Clinical Outcomes of Neoadjuvant Therapy, Conversion Therapy and Palliative Therapy in Gastric Cancer | NCT05203549 | ||
| A Prospective Observational Study on the Potential Benefit of Neoadjuvant Therapy for Advanced Gastric Cancer Based on Organoid Drug Susceptibility Screening | NCT05442138 | ||
| Q-GAIN (Using Qpop to Predict Treatment for GAstroIntestinal caNcer) | NCT04611035 | ||
| Cystic Fibrosis | Response to CFTR-modulators in Intestinal Organoids of Patients with CF Having at Least One R334W Mutation | NCT04254705 | |
| Biliary Tract Cancer | A Prospective Feasibility Study of Multi-Platform Profiling Using Biospecimens From Patients With Resected Biliary Tract Cancer | NCT04561453 | |
| Preclinical Evaluation | Pancreatic Cancer | Establishing Organoids from Metastatic Pancreatic Cancer Patients, the OPT-I Study | NCT03500068 |
| Development of a Prediction Platform for Neoadjuvant Treatment and Prognosis in Pancreatic Cancer Using Ex Vivo Analysis of Organoid Culture | NCT04777604 | ||
| Development of a Prediction Platform for Adjuvant Treatment and Prognosis in Pancreatic Cancer Using Ex Vivo Analysis of Organoid Culture | NCT04736043 | ||
| Colorectal Cancer | Validation of Organoids Potential Use as a Companion Diagnostic in Predicting Neoadjuvant Chemoradiation Sensitivity in Locally Advanced Rectal Cancer | NCT03577808 | |
| Systemic Neoadjuvant and Adjuvant Control by Precision Medicine in Rectal Cancer (SYNCOPE) - Approach on High-risk Group to Reduce Metastases | NCT04842006 | ||
| Radiation Enteritis, Inflammatory Bowel Diseases | Preclinical Evaluation of Multimodal Therapeutic Strategies in Intestinal Irradiation and Inflammatory Bowel Disease from Organoids | NCT05425901 | |
| Esophageal Cancer | Chemoradioresistance in Prospectively Isolated Cancer Stem Cells in Esophageal Cancer-Organoid: RARE STEM-Organoid | NCT03283527 | |
| Esophagogastric Carcinoma | Molecular Outcome Prediction of Neoadjuvant Systemic Treatment in Esophagogastric Carcinoma | NCT03429816 | |
| Colorectal Cancer | The Exploratory Study of Patient-derived Organoids for the Prediction and Evaluation of Clinical Efficiency Effect of Colorectal Cancer Liver Metastasis | NCT05183425 | |
| Validation of the Three-dimensional Bioprinted Tumor Models as a Predictive Method of the Response to Chemotherapy for Colorectal Cancer With or Without Liver Metastases | NCT04755907 | ||
| Living biobanks | Inflammatory Bowel Disease | Prospective, monocentric cohort aiming at generating 3D organoids from human digestive samples | NCT05294107 |
| Colorectal Cancer | Feasibility of Establishing Patient-Derived Organoids for Rectal Cancer: A Biospecimen Collection Protocol | NCT04371198 | |
| Tumor Immune Microenvironment Involvement in Colorectal Cancer Chemoresistance Mechanisms: a Patient-derived Tumoroids Prospective Collection From Systemic Treatment Naive Tumors | NCT05038358 | ||
| Colorectal Cancer Metastases and Hepatocellular Carcinomas | Next Generation “ of Liver Derived-organoïd Biobank: Case of Colorectal Cancer Metastases and Hepatocellular Carcinomas | NCT05384184 | |
| Liver, Biliary and Pancreatic Cancer | A Study Designed to Develop in Vitro Models of Liver, Biliary and Pancreatic Cancer for the Investigation of Tumour Biology and Potential Therapies | NCT02436564 | |
| Primary Sclerosing Cholangitis | Characterization of Biliary Cell-derived Organoids From Bile of PSC and Non-PSC Patients | NCT04753996 | |
| Pancreatic Cancer | EUS-guided Biopsy of Pancreatic Mass Lesions for Developing Patient -Derived Cancer Models | NCT03140592 | |
| Mechanism exploration | Host-microbiota Interactions | Establishment of Human Organoid Lines as a Tool to Dissect Molecular Pathways of Host-microbiota Interactions | NCT05323357 |
| Allergy and Gastrointestinal Disorders | Establishment of Small Intestinal Human Organoids to Check the Influence of Nutrient Antigens or Therapeutic Agents | NCT03256266 | |
| Improving the Diagnosis of Food Allergy and Food Intolerance by Determining Mucosal IgE and Inflammatory Markers and Validating With Intestinal in Vitro Organoids | NCT05259826 | ||
| Bestimmung Des Einflusses Von Nahrungsmitteln Auf Die Darmschleimhaut Mit Der Konfokalen Laserendomikroskopie Und Humanen in Vitro Organoiden | NCT05056610 | ||
| Intestinal Stem Cells Characterization | Intestinal Stem Cells Characterization in Intestinal Organoid Culture from Inflammatory Bowel Disease and Intestinal Polyposis Patients | NCT02874365 | |
| Specimen acquisition | Evaluation and Comparison of the Growth Rate of Pancreatic Cancer Patient-derived Organoids Generated from Matched Fine Needle Aspirations (FNA) and Fine Needle Biopsies (FNB) | NCT03990675 | |
| The biology of innervated sensory epithelial cells | The Innervation of Human Gut Sensory Epithelial Cells | NCT02888587 | |
| The physiopathology of Necrotizing Enterocolitis | Development and Use of a Tissue and Human Enteroid Biorepository to Study the Pathophysiology of Neonatal Necrotizing Enterocolitis | NCT04549727 | |
| The gut epithelium properties in hypertension | Gut Inflammation and Gut-Gut Microbiome Interactions in the Pathogenesis of Hypertension | NCT04497727 |