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. 2022 Sep 13;13:994019. doi: 10.3389/fimmu.2022.994019

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Copyright © 2022 Qu, Zhao, Lin, Wang, Li, Li, Zhang and Shi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Construction of a M2-like TAM-related prognostic signature. (A) Survival status and risk scores of HCC patients in high- and low-risk groups in the training set. Green dots denote low risk and red dots denote high risk. (B) Kaplan–Meier survival curves showed a significantly worse prognosis for the high-risk group in the training set. (C) ROC curves for 1, 3, and 5 years and their AUCs. (D–F) The results of univariate analysis, multivariate analysis, and C-index indicated that risk score was an independent risk factor influencing survival status in preference to other indicators. (G) Results of GSEA analysis. TAM, tumor-associated macrophage; HCC, hepatocellular carcinoma; ROC, receiver operator characteristic; AUC, area under curve; C-index, Concordance index; GSEA, gene set enrichment analysis.