Figure 3.

SARS-CoV-2 infection status alters secreted antibody responses to booster vaccination

(A) IgG spike-binding titers in culture supernatant expressed as AU/IgG.

(B) Fold-change day 60 over baseline of IgG spike-binding titers in culture supernatant.

(C) Ratio of B.1 D614G to variant IgG spike-binding titers in serum and culture supernatant.

Culture supernatant titers represent spike-binding IgG per total IgG. Horizontal lines represent geometrical means and coloring scheme matches groups described in Figure 1A. Statistical analyses by mixed-effects model (A), Kruskal-Wallis followed by pairwise Mann-Whitney tests (B), or Wilcoxon signed rank test (C). ^∗∗p ≤ 0.01, ^∗∗∗p ≤ 0.001, and ^∗∗∗∗p < 0.0001.

See also Figure S4 and Tables S5 and S6.