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. 2022 Sep 13;13:1007089. doi: 10.3389/fimmu.2022.1007089

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Copyright © 2022 Li, Kenney, Park, Fiches, Liu, Zhou, Biswas, Zhao, Que, Santoso, Martinez-Sobrido, Yount and Zhu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IL-8 is induced by Nsp14 and in SARS-CoV-2 infected lung tissues. (A, B) HEK293T-ACE2 cells were infected with wild-type SARS-Cov-2 viruses. Cells were harvested at 24 h. Total RNAs were extracted, and the expression of viral genes (Nsp14, N-protein, A) or cytokines (IL-6, IL-8, B) was analyzed by RT-qPCR and normalized to mock infection. Results were calculated from 3 technical repeats and presented as mean +/- standard error of the mean (SEM). (* p<0.05; ** p<0.01; by unpaired Student’s t-test). (C, D) Dissected lung tissues from COVID19 patients (C, donors #144452, #144511, #144538) or non-infected donors (D, donors #438, #439) were analyzed for IL-8 expression by immunofluorescence (green). Nuclei were stained with Hoechst (blue). Scale bar: 100 µm.