Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Sep 23;219(12):e20221006. doi: 10.1084/jem.20221006

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 Wang et al.

This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Figure S3. — Frequency distribution of human V genes. (a–c) Comparison of the frequency distribution of human V genes for heavy chain and light chains of anti-RBD antibodies from this study and from a database of shared clonotypes of human B cell receptor generated by Soto et al. (2019). Graph shows relative abundance of human IGHV (left panel), IGKV (middle panel), and IGLV (right panel) genes in Sequence Read Archive accession SRP010970 (orange), antibodies obtained from Delta breakthrough infection (green), and Vax2 (blue). (d–f) Same as panels a–c. Graph shows relative abundance of human IGHV (left panel), IGKV (middle panel), and IGLV (right panel) genes in Sequence Read Archive accession SRP010970 (orange), antibodies obtained from Omicron BA.1 breakthrough infection (green), and Vax3 (blue). (g–i) Graph shows relative abundance of human IGHV (left panel), IGKV (middle panel), and IGLV (right panel) genes of antibodies obtained from Delta breakthrough infection (orange) and from Omicron BA.1 breakthrough infection (blue). Statistical significance was determined by two-sided binomial test. *, P ≤ 0.05; **, P ≤ 0.01; ***, P ≤ 0.001; ****, P ≤ 0.0001.