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. 2022 Sep 13;9:979667. doi: 10.3389/fnut.2022.979667

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Copyright © 2022 Fernandes, Sales, Santos, Caparbo, Murai and Pereira.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Quality of life and new symptoms related to COVID-19. (A) Quality of life was assessed using the 36-Item Short Form Health Survey (SF-36) at 6 months. Values are mean ± SD. Data were analyzed using an independent T-test and generalized estimating equations (GEE) with normal distribution and identity link function with the first-order autoregressive correlation matrix. ¹P-value represents a 2-tailed independent t-test comparison. ²P-value represents the main effect of the group adjusted by the length of hospital stay. (B) Frequency of new symptoms from hospital discharge to 1 year of follow-up. Values are n (% within the group). Proportions were compared between groups using chi-square tests (χ²). New symptoms were missing for 11.8% of patients (n = 9 in the placebo group and n = 8 in the vitamin D₃ group) due to a lack of contact during follow-up.