Figure 1.

Effects of once-daily administration of desHis¹Pro⁴Glu⁹-glucagon or desHis¹Pro⁴Glu⁹-glucagon (Lys¹²PAL) (each at 25 nmol/kg bw) for 18 days on cumulative food intake (A), cumulative fluid intake (B), body weight (C) and blood glucose (D) in HFF-STZ mice. Measurements were taken 6 days prior to and throughout the treatment period, at regular intervals. The treatment period is highlighted by the horizontal black bar parallel to x-axis. Values are mean ± s.e.m. (n = 8). *P < 0.05, **P < 0.01, ***P < 0.001 compared to HFF-STZ saline controls. ^ΩP < 0.05 compared to HFF saline controls.