Figure 6.

Effects of once-daily administration of desHis¹Pro⁴Glu⁹-glucagon or desHis¹Pro⁴Glu⁹-glucagon(Lys¹²PAL) (each at 25 nmol/kg bw) for 18 days on locomotor activity in HFF-STZ mice. Mice were placed in CLAMS metabolic chambers for 18 h to acclimatise, and measurements were obtained over a further 24 h period (12 h dark period as shown by black bar parallel to x-axis) at the end of the treatment period. Activity counts on x-axis (A, B and C) and z-axis (D, E and F) were recorded at 60-s intervals. Overall incremental data are presented in panels B, C, E and F, where each data point represents information collected at individual time-points over the 24 h period. Values are mean ± s.e.m. (n = 6). *P < 0.05, **P < 0.01 compared to HFF-STZ saline controls. ^ΩP < 0.05, ^ΩΩP < 0.01, ^ΩΩΩP < 0.001 compared to HFF saline controls.