Fig. 3.

Features of each MCI subtype. (A) Cerebrospinal fluid (CSF) Aβ(1–42) level, (B) CSF tTau level, (C) CSF pTau level, (D) tTau/Aβ(1–42) ratio, (E) pTau/Aβ(1–42) ratio, (F) normalized brain-ventricular volume, (G) normalized hippocampal volume, (H) normalized whole-brain volume, (I) normalized entorhinal cortex volume, (J) normalized white matter hyperintensity (WMH) volume, (K) age, and (L) dosage of APOE ε4 alleles. The blue and red lines indicate the cut-off values based on the CN subjects and the AD dementia patients. The adopted cut-off value was that which distinguished the CN subjects and the AD dementia patients with the highest accuracy in the ROC analysis. Points below the blue line or above the red line represent levels similar to those observed in AD dementia patients. (M) The spot matrix shows the proportions of individuals with features similar to those of AD dementia patients. The spot size represents the proportion of MCI subjects with values exceeding the cut-off value. Yellow indicates a value greater than 50% of the proportion. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)