Table 1.
Summary of sample characteristics at baseline.
| CN | MCI | AD dementia | |
|---|---|---|---|
| N | 305 | 480 | 156 |
| Age in years, mean ± SE | 73.7 ± 0.328 | 71.8 ± 0.339 | 74 ± 0.666 |
| Sex (Female:Male) | 162:143 | 200:280 | 69:87 |
| Education year, mean ± SE | 16.3 ± 0.151 | 16 ± 0.127 | 15.5 ± 0.214 |
| CSF Aβ(1–42) (pg/mL), mean ± SE | 1226 ± 25.27 | 964.2 ± 19.94 | 644.6 ± 22.97 |
| CSF tTau (pg/mL), mean ± SE | 238.4 ± 5.128 | 287.4 ± 6.264 | 373.8 ± 11.1 |
| CSF pTau (pg/mL), mean ± SE | 21.9 ± 0.529 | 27.9 ± 0.693 | 37.3 ± 1.18 |
| tTau / Aβ(1–42), mean ± SE | 2.33e-01 ± 9.01e-03 | 3.86e-01 ± 1.32e-02 | 6.51e-01 ± 2.45e-02 |
| pTau / Aβ(1–42), mean ± SE | 2.19e-02 ± 9.78e-04 | 3.82e-02 ± 1.43e-03 | 6.52e-02 ± 2.55e-03 |
| Whole-brain volume / ICV, mean ± SE | 6.94e-01 ± 2.52e-03 | 6.83e-01 ± 2.28e-03 | 6.45e-01 ± 3.37e-03 |
| Hippocampus volume / ICV, mean ± SE | 5.01e-03 ± 3.37e-05 | 4.5e-03 ± 3.74e-05 | 3.84e-03 ± 5.27e-05 |
| Brain-ventricular volume / ICV, mean ± SE | 2.14e-02 ± 5.9e-04 | 2.45e-02 ± 5.87e-04 | 3.05e-02 ± 9.25e-04 |
| Entorhinal cortex volume / ICV, mean ± SE | 2.58e-03 ± 2.16e-05 | 2.33e-03 ± 2.19e-05 | 1.86e-03 ± 3.48e-05 |
| WMH volume, mean ± SE | 4.03 ± 0.429 | 5.02 ± 0.385 | 4.75 ± 0.539 |
| APOE ε4 carriers (%) | 81 (26.6%) | 239 (49.8%) | 108 (69.2%) |
Abbreviations are as follows: CN, Cognitively normal; MCI, Mild cognitive impairment; AD, Alzheimer's disease; CSF, Cerebrospinal fluid; Aβ, Amyloid-beta; tTau, Total tau; pTau, Phosphorylated tau; ICV, intracranial volume; WMH, White matter hyperintensity; APOE, Apolipoprotein E; SE, Standard error.