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OBP-702 induces p53-mediated apoptosis and autophagy in human PDAC cells
(A and B) Human PDAC cells with WT-p53 (A) and mt-p53 (B) were infected with OBP-301 or OBP-702 at the indicated MOI for 48 h. Cell lysates were prepared and subjected to western blot analysis of p53, E1A, PARP, cleaved PARP (C-PARP), and p62 expression. β-Actin was assayed as a loading control. Uninfected (mock-treated) cells were shown as virus-infected cells at an MOI of 0.
