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. 2022 Sep 13;13:932252. doi: 10.3389/fimmu.2022.932252

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Copyright © 2022 Casasola-LaMacchia, Seward, Tourdot, Willetts, Kruppa, Agostino, Bergeron, Ahyi-Amendah, Ciarla, Lu, Kim, Hickling and Neubert

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Length distribution of HLAII-associated peptides in monocytic DCs. (A) Length of total HLAII immunopeptidome in 126 data sets where each dot represents a detected peptide. (B) Frequency distribution of peptide length from a representative donor (D1237), where each bar corresponds to the number of peptides identified at a given residue-length. (C) HLAII peptide length distribution from different conditions was analyzed by frequency (D1237). Each bar corresponds to the number of peptides identified at a given residue-length in samples treated with INFL (blue), ADAL (green) and Fab’ (orange) antibodies either alone (light color) or TNF-bound (bold color).